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Are statins as risky as people say?

The gap between perception and evidence here is unusually wide. Serious side effects are rare; muscle aches are the common complaint, and in blinded trials the rate of muscle symptoms is close to that on placebo, which suggests expectation plays a large role. A modest increase in diabetes risk exists and is outweighed by cardiovascular benefit in those who need them. What matters is whether you actually need one, which depends on overall risk rather than the cholesterol number alone. If you have side effects, alternatives exist — changing the statin, the dose, or the timing usually resolves it.

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'Whether you need one depends on overall risk, not the number' is the part that gets lost in the argument.

Arjun Nair · 0 upvotes

The blinded trial finding about muscle aches is remarkable and not widely known.